Two sample MR report
HLA-A_Conventional Dendritic Cell against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 55 | 0.0312780 | 0.1152112 | 0.7870736 |
| Weighted median | 55 | -0.0544083 | 0.0111254 | 0.0000010 |
| Inverse variance weighted | 55 | -0.0609435 | 0.0082393 | 0.0000000 |
| Simple mode | 55 | -0.0827389 | 0.0239600 | 0.0010848 |
| Weighted mode | 55 | -0.0409396 | 0.0240207 | 0.0940639 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 26.62204 | 53 | 0.9990723 |
| Inverse variance weighted | 27.26607 | 54 | 0.9990992 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0508146 | 0.0633195 | 0.4258416 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0012837 | 0 | TRUE | 0.0006749 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
